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It is known that the insulin resistance (i.e., the insensitivity of cells, in particular, hepatocytes, skeletal muscle cells, and adipocytes to insulin, the primary hormone in glucose homeostasis in the fed state) predisposes to T2DM

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Research suggests that it is important in cellular adaptation to molecular stress and that deficiencies in this protein may play a key role in tumor aggressiveness

[Abstract] J Am Chem Soc