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Insulin-like growth factor-I (IGF-I) analogue, LR(3)IGF-I, ameliorates the loss of body weight but not of skeletal muscle during food restriction

Kuma E, Lourida I, Moore SF, Levine DA, Ukoumunne OC, Llewellyn DJ

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Two possible explanations for this effect are proposed: (1) reduced food intake due to an irritant effect of the treatment on the gastrointestinal tract (255, 256) or (2) a stimulant effect of TTFD on metabolism via enhanced noradrenaline secretion and thermogenesis (257)