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This is a critical issue, as a decrease in muscle mass leads to a reduction in basal metabolic rate [41, 42], which could hinder the long-term benefits of obesity treatment by impairing the overall metabolic profile

What can be said is that the triple-agonist mechanism appears to produce a steeper dose-response curve than either the dual-agonist (tirzepatide) or single-agonist (semaglutide) approach

Studies show a dramatic initial weight loss that slows after 60 weeks as the appetite-suppressive effects appear to diminish

Let us build a decision framework that accounts for all the relevant variables

This article demonstrates the efficacy of tirzepatide for treatment of MASH

These indications represent future expansion zones and a growing threat to narrowly targeted pipelines