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Although systemic inflammation is known to modulate iron metabolism, such as interleukin-6 (IL-6) stimulating hepcidin synthesis and subsequently downregulating FPN1, this has been observed primarily in hepatic tissues (95)

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10.1016/j.tcb.2007.07.009 Trends Cell Biol

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Gut microbiota: primary producers of trimethylamine Gut microbiota, particularly Firmicutes and Proteobacteria , are key mediators of TMA production through distinct enzymatic pathways (51, 52)

Clinicians emphasize the importance of monitoring vitamin and mineral levels to avoid toxicity, especially with high doses of certain nutrients such as vitamin A, folic acid, and zinc