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Injection will be administered according to updated international protocols

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The visceral fat-reducing effects involve multiple mechanisms including direct stimulation of lipolysis in adipocytes, promotion of fatty acid oxidation in liver and muscle, and selective effects on visceral adipose tissue due to higher density of receptors in visceral fat cells

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443 Unfortunately, the trial results showed that CSL112 did not significantly reduce the composite primary endpoint, challenging the longstanding hypothesis that direct enhancement of HDL function would provide clinical benefits