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GO analysis of upregulated DEGs indicated that MASLD affected multiple aspects of muscle biology, primarily involving immune system activation, inflammatory response, and hormone- and cytokine-related processes (Fig

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[1] Additionally, patients using Mounjaro with insulin or sulfonylureas should be aware of the increased hypoglycaemia risk and may need dose adjustments of these medications

Further work would be required to delineate whether histaminergic neuron activation in these conditions was mediated by the hypoglycemia or insulin itself

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