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In the current HepG2 cell model, in which prolonged exposure is not feasible, the use of relatively high QI concentrations in a short timeframe allows for the identification of underlying mechanisms and pathways, as has been done previously in similar studies with hepatic toxicants (Tafazoli and OBrien, 2009

Glutathione nasal spray is a sterile solution of reduced glutathione (GSH) compounded for intranasal use

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Apart from the remethylation to Met, Hcy also drives the synthesis of cystathionine via cystathionine -synthase (CBS)