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Lambadiari et al., 2018), at least in part due to reduced atherosclerosis owing predominantly to the anti-inflammatory properties of the drug class (Rakipovski et al., 2018

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So the hypothalamic satiety pathways and dopamine reward circuits are changing

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Yes, as your body weight decreases, your basal metabolic rate and total calorie requirements naturally reduce, so calorie intake should be periodically reassessed with your healthcare provider to ensure continued safe and effective weight management