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An injection of group B Streptococcus, a major bacterial pathogen in pregnant women and neonates, impaired social behavior, decreased social interaction, and decreased USVs when inoculated in late gestation in rats (179, 180)

In parallel, causal in vivo studies targeting key structural regulators of these contact sites, such as MFN2 and other tethering proteins, will be particularly informative for determining whether disruption of organelle interaction hubs directly contributes to mitochondrial dysfunction, metabolic imbalance, and functional ovarian decline

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Montgomery, L.J