Acknowledgements This work was co-funded by the German Research Foundation (DFG), the State of North Rhine-Westphalia (NRW), the European Union (European Regional Development Fund: Investing In Your Future) (EFRE-800400), DDHD (Drug Discovery Hub Dortmund), the German Federal Ministry of Education and Research (InCa, 01ZX2201B), the Mercator Research Center Ruhr (MERCUR, IGNITE (Ex-2021-0033)), the German Cancer Aid ((Deutsche Krebshilfe), Targeting Transcriptional Addiction in Cancer (TACTIC (70115201) is part of the preclinical cancer drug development network (preCDD))), the Netzwerke 2021 program, an initiative of the Ministry of Culture and Science of the State of North Rhine-Westphalia (CANcer TARgeting, NW21-062 C) and, supported by the European Synchrotron Radiation Facility (ESRF, Grenoble, France, proposal MX-2580, beamline ID30B

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