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Clozapine-induced reduction of l-carnitine reabsorption via inhibition/down-regulation of renal carnitine/organic cation transporter 2 contributes to liver lipid metabolic disorder in mice

Strengths of our study include the incorporation of high-dimensional datasets with validated profiling tests in a schizophrenia population such that acyl-carnitines with abnormalities in cellular bioenergetics are characterized in schizophrenia

Both drugs are GLP-1 receptor agonists that curb appetite and regulate blood sugar, especially when paired with healthy habits

Mixed-effects repeated measures models were used to explore quality of life (QOL) score changes over time

Many patients report feeling significantly better within 24-48 hours of treatment

Calories are tracked, exercise is consistent, and lifestyle changes are sustained but the scale barely moves