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Assessment of Diabetes Therapy-Related Quality of Life Scale The DTR-QoL questionnaire is a Japanese diabetes-specific HRQoL measure that contains 29 items (Table S1) to assess the influence of diabetes treatment on HRQoL across four domains [28]: burden on social activities and daily activities

257 Disruption of the colonic barrier is the most common pathological change in animal models of UC, and studies have shown that the SGLT2 inhibitor empagliflozin can significantly increase the expression of SIRT-1, suppress the levels of PI3K and AKT, and increase the levels of tight junction proteins (claudin-1 and occludin), thereby improving the integrity of the colonic barrier

All average concentrations were higher than those in the plasma

Atom names, atom kinds, or other criteria specified in the simulation system was used to make this decision

As a water-soluble vitamin, the body does not retain it for extended periods