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If a vial was left out for an extended period, do not assume it is still good

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Phase 3 TRIUMPH-1 NCT05929066, TRIUMPH-2 NCT05929079, TRIUMPH-3 NCT05882045, TRIUMPH-4 NCT05931367, TRIUMPH-Outcomes NCT06383390

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The cAMP-PKA-STAT3 pathway is related to M2 differentiation, and there is another p-STAT1 protein whose phosphorylation is inhibited by GLP-1RAs, which is an M1 phenotype (Li et al., 2019)