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Step 7: Mix Gently Gently swirl the vial in a slow circular motion until the powder is fully dissolved

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Harlan's research highlights a crucial breakthrough: "By the late 1970s, physicians at Mayo Clinic thoroughly understood how to prevent, treat, and avoid TSW and continued to use low potency topical steroids on the face for chronic recurring dermatitis." [12] This understanding would eventually lead to the development of safer formulations that could manage perioral dermatitis without triggering the dependency cycle