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In 2013, we developed a mathematical model corresponding to the above diagram (Ben-Shachar et al

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Regarding basal cortisol, children with PWS are generally able to produce adequate levels in daily life, as demonstrated by studies showing normal average morning basal serum cortisol (6466) or salivary cortisol (51)

However, OPG knockout results in osteoclast-mediated cartilage erosion, leading to disorganized alignment of CEPs, enhanced bone formation or neovascularization, and elevated inflammatory factors in mice (6567)

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