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Mistake 4: Expecting results in 4 weeks and quitting

(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field

No long-term knee-specific safety data exists

If your levels were already normal, you may notice more subtle benefits at first

Key Factors That Influence Recovery Severity of deficiency: Lower levels may take longer to correct