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For instance, trimethylamine N-oxide (TMAO), a metabolite derived from gut microbial activity, has demonstrated the ability to stimulate immune activation and enhance the efficacy of immune checkpoint blockade (ICB) in mouse models of pancreatic cancer

Truncated soluble His 6x tagged human FcRn lacking the transmembrane domain (hFcRn-His) was produced in a Baculovirus expression system and purified using a HisTrap HP column (Cytiva Life Sciences) 68,69

If combining, start with lower doses of each to assess the combination

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