For context, the dual agonist tirzepatide is studied in SURMOUNT ( NEJM , 2022) and SURMOUNT-OSA ( NEJM , 2024)
Restoration of bile acid metabolism, specifically the microbial conversion of cholic acid to deoxycholic acid, correlates with increased colonic and serum 5-HT concentrations and elevated expression of tryptophan hydroxylase 1, the rate-limiting enzyme in peripheral serotonin biosynthesis [18]
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