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Common signs and symptoms include: Yellowish skin, known as jaundice Yellowish whites of the eyes, known as icterus Fatigue or fussiness Painful swelling of the hands and feet Frequent infections, especially pneumonia Fatigue and weakness Episodes of pain, called sickle cell crises, which occur when sickled red blood cells block blood flow to the limbs and organs Pernicious anemia may cause symptoms similar to other anemias as well as symptoms related to a vitamin B12 deficiency: Tingling and numbness in hands and feet Muscle weakness Loss of reflexes Loss of balance Trouble walking Weakened bones, leading to hip fractures Neurological problems, such as confusion, dementia, depression, and memory loss Nausea, vomiting, heartburn, abdominal bloating and gas, constipation or diarrhea, loss of appetite, and weight loss Enlarged liver Smooth, thick, red tongue Poor reflexes or unusual movements like face tremors Difficulty feeding due to tongue and throat problems Irritability Permanent growth problems if left untreated Anemia of chronic disease may cause similar signs and symptoms to other anemias, such as: Fatigue Pale skin Light-headedness Shortness of breath Rapid heartbeat Irritability Chest pain Causes and Risk Factors for Anemia While white blood cells fight infection, and platelets help your blood clot, red blood cells carry oxygen throughout your body

6 Conclusion Oxidative stress, defined as an imbalance between the production of reactive oxygen species ROS and antioxidant defenses, plays a pivotal role in the pathogenesis of major diseases, including cardiovascular disorders, diabetes, cancer, and neurodegenerative conditions

Efficacy and Safety of Glucagon-Like Peptide-1/Glucagon Receptor Co-Agonist JNJ-64565111 in Individuals With Obesity Without Type 2 Diabetes Mellitus: A Randomized Dose-Ranging Study

Results and Discussion According to the mechanisms of the dioxin-inducing fatty liver and the actions of carnitine at these mechanisms, the following sections summarized the results that explained why carnitine could be a promising agent against dioxin toxicity

(June 10, 2025)