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This leads to effective skin lightening, reduction in pigmentation, and a brighter, more radiant complexion with consistent use

These include serotonin and dopamine, which influence mood, sleep, and emotion, and cortisol, which helps the body deal with stress

Management recommendations are given in Box 22.1

VD modulates neuroinflammation by suppressing TLR/NF-B signaling, reducing pro-inflammatory cytokines (IL-1 and TNF-) while simultaneously enhancing neurotrophin expression (BDNF and NT-3) and stabilizing calcium homeostasis through L-type channel regulation

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Current evidence does not establish a causal link between GLP-1-based therapies and increased overall cancer risk in humans, though ongoing monitoring continues as these medications are used by growing numbers of patients over longer time periods