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Also, the percentage of mean change was calculated for each subject from baseline to week 5 and from baseline to week 10, and then MannWhitney test was employed to determine the difference in the mean of the percentage of mean difference between the two groups

When prescribed appropriately and monitored by a licensed provider, it is considered safe for most patients

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Second, many available studies are characterized by small sample sizes or lack appropriate control groups, making it difficult to draw definitive conclusions about therapeutic efficacy and optimal treatment protocols

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