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Retatrutide is not FDA-approved and should only be used in research settings following trial protocols

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Biology is complex, and these findings remind us not to over-interpret early signals, whether positive or negative

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Nausea, irregular bowel movements, bloating, and constipation are among the most common concerns reported by GLP-1 users

Case reports of refractory gastric residue and failed NPO status under propofol sedation prompted the American Society of Anesthesiologists (ASA) in 2023, and a broader multisociety coalition in 2024, to recommend temporary discontinuation of GLP-1RAs before elective procedures [6,7]