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A 2026 study published in The Lancet Obstetrics, Gynaecology & Womens Health found that combining GLP-1 therapy with HRT produced greater mean weight loss than GLP-1 alone in this patient population

For people on concurrent diabetes medications like metformin, insulin, or sulfonylureas, this transition window requires careful blood sugar monitoring, sometimes several times daily

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[3] GLP-1 can: Slow how fast your stomach empties (gastric emptying), so you feel full longer