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Includes pharmaceutical-grade GLP-1 medication (semaglutide), comprehensive medical consultation, injection training and all supplies, basic nutritional guidance, and follow-up scheduling

The final summary information was shown in Supplementary Tables 13

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Although the lipidation of GLP-1 peptides can enhance their binding to albumin, significantly increasing their half-life (this is currently a widely adopted pharmacokinetic enhancement strategy for GLP-1 peptides), lipidation modification is not universally applicable

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Additionally, inflammation and dysbiosis can lead to systemic effects, contributing to chronic conditions like CKD and neuroinflammation (Adesso et al., 2017)