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This results in an array of effects, including the release of additional energy for necessary physiological functions to respond to the stressor

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On the other hand, the transcription factor Nrf2 (NF-E2 p45-related factor 2) regulates the expression of anti-inflammatory and antioxidant NADPH, NAD(P)H quinone oxidoreductase 1, glutathione peroxidase, ferritin, hemeoxygenase-1 (HO-1) and other detoxifying enzyme genes

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Ethics declarations Conflict of interest The authors have no competing interest to declare that are relevant to the content of this article

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If glutathione levels fall, the reactive NAPQI metabolite can combine with various structural proteins and other vital molecules and thereby cause toxicity

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Although protein leak decreases ATP production per one mitochondrion, consistent uncoupling has been shown to trigger mitochondrial proliferation and thus a net increase in ATP per cell in the hippocampus, protecting mice against seizures (77)

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