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Furthermore, they also found that 'a balanced dual agonist in mice engineered to lack GLP-1 receptors still induced weight loss, proving that the compounds were not causing weight loss purely by targeting GLP-1' (Molteni, Chen)

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doi: 10.1111/jfbc.14166 57 HeshmatiJSepidarkishMMorvaridzadehMFarsiFTripathiNRazaviMet al

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At equal molar concentrations (based on the optimized amount for DDA), we found that both C10 and C12 (DDA) are equivalent and both induced a facile phase transfer while C4 did not