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Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes - Results of a hyperglycaemic glucose clamp study

Etomoxir, a CPT1 antagonist, binds specifically to CPT1 and thus prevents the formation of acyl-carnitine, which is a necessary step for the transport of fatty acyl-CoA into the mitochondria 16

Human relevance would require sufficient published, peer-reviewed controlled human studies, appropriate regulatory review, pharmacokinetic characterization, toxicology data, and long-term safety evaluation