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Gradual dose escalation helps mitigate these effects

Figure 2 2.1 Depletion of M2 TAMs Macrophages account for 60% of the cellular components in the tumor, and with the progression of the tumor the macrophages in TME are dominated by M2 TAMs which promote tumorigenesis and metastasis, and based on this reducing M2 TAMs in TME can eliminate the pro-tumor effects of macrophages (13)

A total of 13 patients received ARD-101 at a fixed dose of 200 mg twice daily for 28 days, or about one month

Pall, East Hills, NY)

Reduce la secrecin de glucagn