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Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes

Research shows improvements in multiple cardiovascular risk factors including blood pressure reduction (typically 2-5 mmHg systolic), improved lipid profiles with decreased LDL cholesterol and triglycerides, and reduced inflammatory markers like C-reactive protein

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2024;doi:10.1056/NEJMoa2403347) demonstrated that addition of semaglutide (Ozempic/Wegovy, Novo Nordisk) to an SGLT2 inhibitor showed no renal protective effect (HR = 1.07, 95% CI 0.69-1.67), although the number of subjects receiving an SGLT2 (16%) in this study was relatively small

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