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Reduced Joint Deterioration: Histological analysis in animal studies showed that AOD-9604-treated joints had lower degeneration scores compared to untreated controls
DOI: 10.1038/s41423-022-00902-0
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Subsequently, nucleus translocation of PARP1-dependent AIF interacts with macrophage migration inhibitory factor (MIF) to format the AIF-MIF complex, which further induces the DNA breakage and ultimately results in parthanatos [140]
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Third: it's almost certainly temporary
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