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A pilot study in young adults found that lion mane supplementation improved processing speed, and researchers attributed this partly to BDNF-like neurotrophic effects

author reply e190-192 Scheidegger KJ, James RW, Delafontaine P: Differential effects of low density lipoproteins on insulin-like growth factor-1 (IGF-1) and IGF-1 receptor expression in vascular smooth muscle cells

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Dolatshahi M, Ranjbar Hameghavandi MH, Sabahi M, Rostamkhani S (2021) Nuclear factor-kappa B (NF-B) in pathophysiology of Parkinson disease: diverse patterns and mechanisms contributing to neurodegeneration

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the authors, however, suggest that larger cohorts or casecontrol studies should be conducted to replicate these findings