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The mechanisms by which certain medications bring about oral mucosal melanin hyperpigmentation include upregulation of tyrosinase activity, deposition of complexes of the drug with pre-existing melanin in the mucosa, or induction of local inflammatory reactions with the triggering of melanin production [11, 38]
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Researchers estimate a 10% increase in antioxidants could lead to reduced time spent in hospital for those with psychosis
The development of novel techniques for ultra-sensitive -synuclein detection, particularly real-time quaking-induced conversion [108], could improve the accuracy of identifying prodromal PD and serve as reliable biomarkers for treatment response