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LDL cholesterol decreased

GLP-1 receptor agonists are licensed for type 2 diabetes and weight management, not specifically for cholesterol reduction

See the difference for yourself: 83% of commercial insurance plans require prior authorization, step therapy, or both before a patient can access a GLP-1 prescribed for obesity

It has years of data showing real cardiovascular benefits, while retatrutides long-term impact is still unknown

However, similar to other chronic diseases such as T2D, the focus in obesity management (including pharmacotherapy prescription) over time will need to be shifted to primary care and collaborative integrated care models to be developed between specialist obesity services and primary care striving to meet the needs of people living with obesity [115]

[1] That extra glucagon receptor is the energy-burning piece the two-receptor drug simply doesnt have