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In addition, brain insulin resistance affects tau metabolism and promotes the hyperphosphorylation of tau proteins, tau protein aggregation, the formation of paired helical filaments, and the further formation of NFTs (Mohandas et al., 2009)

Some argue that these traits do not independently cause neurodevelopment outcomes

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IGF-1 has been implicated in the development of acne vulgaris by stimulating sebum production. The authors noted the study had limitations, including the fact that it only looked at formally diagnosed acne, which might miss milder cases