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Since the great majority of circulating IGF-I is normally sequestered in IGFBP complexes, an analogue that escapes that buffering behaves very differently in any system containing binding proteins, and that is the reason the IGF 1 LR3 variant exists as a reagent at all

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Appetite remains suppressed, but without the accompanying gastrointestinal distress that made eating difficult during month 2

10.1166/jbn.2021.3031 70 MaY.ChenF.YangS.ChenB.ShiJ