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[7] (This interaction is not significant when levodopa is combined with carbidopa, as in standard carbidopa/levodopa therapy, because carbidopa prevents peripheral levodopa breakdown.) Another notable interaction involves the chemotherapeutic agent altretamine: coadministration of pyridoxine can decrease altretamines effectiveness and is generally advised against unless specifically directed

When NAD levels decline, it results in a decrease in cellular energy, which can also be described as mitochondrial dysfunction a condition that is implicated in most chronic illnesses, including diabetes, autoimmune disorders, Alzheimers, multiple sclerosis and many more

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Contributed by Lananh Nguyen, MD and Jeffrey Kant, MD, PhD