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357 IR in adipose tissue leads to high FFAs levels, 358 visceral fat accumulation that is associated with elevated levels of plasminogen activator inhibitor 1 (PAI-1) and BP, 359 and ectopic lipid and toxic lipid metabolite accumulation (lipotoxicity) in blood vessels that alters cellular signaling and cardiac structure, thereby contributing to the increased prevalence of cardiovascular diseases

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Kim JK, Kim J, Lee SM, Lee J, Lee SH, Choi IY (2019) 991-P: Potential of a Novel Long-Acting Glucagon Analog, HM15136, for the Treatment of Obesity

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