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illustrated how the selective permeability of the blood-brain-barrier (BBB) and bloodCSF barrier, combined with the spatial distribution of glutathione-metabolizing enzymes, underlies region-specific vulnerability to oxidative injury in the CNS (9)

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4.2 Detailed expandable studies Study 1: Imai & Guarente 2014, foundational review article Citation: Imai S., Guarente L

VPA is a branched chain carboxylic acid (2-propylpentanoic acid or di-n-propylacetic acid), with a chemical structure very similar to that of short chain fatty acids (Fig