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This is leading towards increasing R&D in clinical trials for medical devices and medicines

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Additionally, GLP-1 RAs with established CV benefitsspecifically liraglutide, subcutaneous semaglutide, dulaglutide, and efpeglenatideare recommended for patients with T2DM and ASCVD to reduce CV events, regardless of baseline or target HbA1c levels or concurrent glucose-lowering therapy (Class I, LoE A)

At the GLP-1 receptor, Tirzepatide activates pathways associated with glycaemic control, gastric emptying, and appetite-related signalling in preclinical models

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[DOI] [PMC free article] [PubMed] [Google Scholar] 127.Psilopanagioti A., Nikou S., Logotheti S., Arbi M., Chartoumpekis D.V., Papadaki H