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In addition, rhein reduces renal fibrosis by promoting Cpt1a-mediated fatty acid oxidation through the Sirt1/STAT3/twist1 pathway (Song et al., 2022), thereby leading to an improvement in renal function and reducing interstitial damage and collagen fiber accumulation by activating the Sirt3/FOXO3a pathway (Wu et al., 2020)

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For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

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These lead to things like food intolerance, leaky gut, and chronic inflammation

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Thus, targeting Th17 cells and their associated pathways has thus emerged as a key therapy strategy for IBD (189192), with metabolic reprogramming of the Th17/Treg balance holding significant promise

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These costs are largely driven by the need for complex production and formulation strategies to address challenges such as poor protein stability and solubility, both in vitro and in vivo, as well as rapid degradation and short half-life, which often necessitate frequent dosing or molecular modifications

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