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The lack of systematic screening for NAFLD has led to it being massively underdiagnosed 8
It consists of the tripeptide glycyl-L-histidyl-L-lysine complexed with a divalent copper ion, forming a high-affinity chelate that facilitates controlled copper delivery within biological systems
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One additional detail about bupropion that becomes relevant when combined with GLP-1 therapy concerns its effect on energy
Specifically, it stimulates the activity of three rate-limiting dehydrogenases: pyruvate dehydrogenase (PDH), isocitrate dehydrogenase (IDH), and -ketoglutarate dehydrogenase (-KGDH) (Denton, 2009)