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NAD + metabolic disturbance NAD + has neuroprotective effects in acute axonal injury, chronic nerve stress, and different neurodegenerative diseases associated with excitotoxicity [116]

Planta 236:765779 Pignocchi C, Kiddle G, Hernndez I, Foster SJ, Asensi A, Taybi T, Barnes J, Foyer CH (2006) Ascorbate oxidase-dependent changes in the redox state of the apoplast modulate gene transcript accumulation leading to modified hormone signaling and orchestration of defense processes in tobacco

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Therapeutic interventions targeting this axis, such as resveratrol, and quercetin, show promise by simultaneously modulating gut-joint signaling and suppressing ferroptosis, potentially achieving intestinal barrier recovery and chondrocyte rescue