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Pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (AKD) play pivotal roles in glycolysis and the Krebs cycle, respectively, since AKD, in the Krebs cycle, helps maintain neurotransmitter levels and supports protein synthesis (37, 39, 40)

The pump mechanism allows for controlled application

GI losses, the use of diuretics, hemorrhages, and endocrine impairments such as adrenal insufficiency, ACTH (adrenocorticotropic hormone) deficit, or severe hypothyroidism are common causes of low sodium levels

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