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Patients should be monitored for allergic or anaphylactoid reactions

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123,124 Therefore, all the pathways and metabolic reactions in which NAD is involved are also altered by aging, and this decreased metabolic activity has been associated with numerous aging-related metabolic diseases, such as diabetes

Additionally, cocaine induces apoptosis in cerebral vascular smooth muscle cells, contributing to vasoconstriction and ischemia, resulting in significant neurological damage (Fonseca and Ferro, 2013)