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Genes Dev (2005) 19(8):87790.10.1101/gad.1295405 183 HolstJJ

argyi, we reported a novel carbon dot derived from Artemisia argyi and then treated with acetic acid (AA-CDs) for OA treatment through a triple-action mechanism: suppressing oxidative stress, regulating iron homeostasis, and targeting the HSPA5-GPX4 pathway

When combined with vitamin C, glutathione is employed and given intravenously

It inhibits NF-kB, the master transcription factor controlling the inflammatory cascade, and is actively transported into inflamed intestinal cells via the PepT1 transporter