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However, the term Metabolic Syndrome has become commonly used since its inception by the Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) in 2001 [1]

In osteoarthritis, oxidative stress causes excessive ROS in chondrocytes, disrupting the binding of Keap1 and Nrf2, allowing Nrf2 to enter the nucleus, activating the antioxidant response element (ARE), and increasing the expression of antioxidant proteins, such as HO-1 and NQO-1 [69], which can attenuate oxidative stress and inflammatory responses and protect chondrocytes

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Al-Zubaidi U, Adhikari D, Cinar O, Zhang Q-H, Yuen WS, Murphy MP, et al

Linearity For the plasma samples, seven-point calibration plots were constructed for all analytes

This dual regulation of transporters, by protein quality control and metabolic sensing, allows for modulation of mitochondrial glutathione levels in response to iron homeostasis, providing avenues for exploring the regulation of metabolic compartmentalization [24]