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p = 0.608), employment ( p = 0.320), psychopharmaceuticals intake ( p = 0.324), previous psychiatric hospitalization ( p = 0.817), previous psychiatric disorder diagnosis ( p = 0.308), smoking habit ( p = 0.285) and higher BDNF levels ( p = 0.366)

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These include the bell-shaped dose-response curve, central effects after peripheral administration, a delayed and prolonged time course, and some penetration of the blood-brain barrier in essentially intact form

however, cases of hypercobalaminemia in leukemia, autoimmune diseases, and pulmonary and renal dysfunction have also been observed (Andrs et al., 2013

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