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In a randomized trial, three months of pasteurized Akkermansia improved insulin sensitivity by nearly 30%, lowered fasting insulin and total cholesterol, and modestly reduced body fat compared to placebo

It upregulates IGF-1 expression in certain regions of the brain, such as the hypothalamus, cerebellum, and hippocampus

These interactions may increase the risk of kidney damage or alter the drugs effectiveness

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Respiratory depression is the chief risk for elderly patients treated with opioids, and has occurred after large initial doses were administered to patients who were not opioid-tolerant or when opioids were co-administered with other agents that depress respiration