Molecular insight into the immune up-regulatory properties of the leaf extract of Ashwagandha and identification of Th1 immunostimulatory chemical entity
One honest caveat from the data: because the Phase 2 curve had not clearly plateaued by the end of the study, the full ceiling of the effect is genuinely not yet known that is one of the questions the Phase 3 TRIUMPH program is designed to answer
The Cys-dependent strategy of NRF2 activation adopted by MSL TNBC cells is all the more interesting as breast cancer is one of the cancers with the lowest number of mutations or copy number variations (CNV) in the KEAP1 , CUL3 or NFE2L2 genes that would lead to constitutive activation of this pathway and are more common in other cancers (Fig
The polymer can be further purified by suitable methods that will enhance gelation properties of the polymer
Moving forward, understanding proteostasis at a systems level, as an interactome rather than a pathway, will be essential for decoding disease mechanisms and designing truly effective therapeutic interventions
Ullah A, Aldakheel FM, Anjum SI, Raza G, Khan SA, Tlak Gajger I (2023) Pharmacological properties and therapeutic potential of honey bee venom
