Pharmacologic options include short courses of anti-inflammatory drugs, neuropathic agents such as gabapentin or duloxetine when indicated, and topical agents for localized pain
The switching guide between GLP-1 compounds covers transition strategies in detail
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Whilst glucagon typically raises blood glucose, early Phase 2 trial data suggest that, when combined with GLP-1 receptor activation, its net effect may include increased calorie burning and a potential reduction in liver fat, without causing clinically significant rises in blood sugar
However, research published in the Annals of Internal Medicine found an important nuance: longer-acting GLP-1 receptor agonists (which includes both tirzepatide and once-weekly semaglutide) were actually associated with lower GERD risk than shorter-acting versions like liraglutide